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Updated: Apr 11, 2026
Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
Published on: June 8, 2019
Absence of DNA viruses in ameloblastomas
Maria K Jauhiainen1,2,3, Jetta Kelppe4, Maria Söderlund-Venermo2
1Department of Otorhinolaryngology-Head and Neck Surgery, Head and Neck Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Abstract:
Ameloblastomas (ABs) are rare odontogenic benign tumors. Although studies of the molecular pathogenesis have revealed the presence of mutations and altered gene expression, the etiology is unresolved. Viruses cause 10%-15 % of cancers, but their potential role within benign tumors is less studied. This study focuses on the potential presence of herpes-, parvo-, and polyomaviruses in ABs. Thirty DNA viruses comprising herpes-, parvo-, and polyomaviruses were analyzed by qPCR and Luminex-based methods in 11 formalin-fixed paraffin-embedded AB samples. In repeated analyses, the ABs harbored none of the studied large set of viruses. Based on our findings a relevant role of the studied viruses seems unlikely in the pathogenesis of ABs.
Insights
This study investigated herpes-, parvo-, and polyomaviruses in ameloblastomas (ABs). Researchers found no evidence of these viruses, suggesting they are unlikely to cause this rare benign tumor.
Area of Science:
- Oncology
- Virology
- Oral Pathology
Background:
- Ameloblastomas (ABs) are rare benign odontogenic tumors with an unresolved etiology.
- While viruses are linked to cancers, their role in benign tumors like ABs is less understood.
Purpose of the Study:
- To investigate the potential presence of herpes-, parvo-, and polyomaviruses in ameloblastoma samples.
- To assess the possible role of these DNA viruses in the pathogenesis of ameloblastomas.
Main Methods:
- Analysis of 11 formalin-fixed paraffin-embedded ameloblastoma samples.
- Quantitative PCR (qPCR) and Luminex-based methods were used to detect 30 different DNA viruses from herpes-, parvo-, and polyomavirus families.
Main Results:
- None of the 30 studied DNA viruses were detected in the ameloblastoma samples after repeated analyses.
- The findings indicate a lack of association between the investigated viruses and ameloblastoma.
Conclusions:
- The studied herpes-, parvo-, and polyomaviruses do not appear to play a significant role in the pathogenesis of ameloblastomas.
- Further research may be needed to explore other potential etiological factors for ameloblastomas.
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