Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"Dual-lock"-controlled activatable nanotheranostics for chemiluminescence resonance energy transfer (CRET)-driven enhanced photoimmunotherapy.

Journal of materials chemistry. B·2026
Same author

Proteomic analysis reveals lipid metabolism disruption and key targets in ARPE-19 cells after RNF13 knockdown.

Scientific reports·2026
Same author

Tumor microenvironment-adaptive nanocatalysts: harnessing pH gradients for selective and synergistic cancer therapy.

Journal of materials chemistry. B·2026
Same author

Cerebrovascular Imaging-to-Graph Reconstruction for Individualized Digital Twin Brains.

bioRxiv : the preprint server for biology·2026
Same author

Dual-quenched and redox-responsive gold nanoplatforms for tumor-specific multimodal theranostics.

Nanoscale·2026
Same author

Targeting NOX4 with Quercetagetin-PLGA nanomaterials: a novel therapeutic strategy for Alzheimer's disease.

Naunyn-Schmiedeberg's archives of pharmacology·2026

Related Experiment Video

Updated: Apr 11, 2026

Taking Advantage of Reduced Droplet-surface Interaction to Optimize Transport of Bioanalytes in Digital Microfluidics
07:57

Taking Advantage of Reduced Droplet-surface Interaction to Optimize Transport of Bioanalytes in Digital Microfluidics

Published on: November 10, 2014

8.4K

A Hybrid Phospholipid Monolayer-Based Interface for Interaction-Enhanced Electrical Detection in Biofluids.

Nan Song1, Duo Chen1, Yun Zhang1

  • 1College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, Hubei Key Laboratory of Electrochemical Power Sources, Institute of Molecular Medicine, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430072, China.

ACS Nano
|April 10, 2026
PubMed
Summary

Researchers improved electrical biosensing by controlling surface charge density and composition. This mitigation of charge screening and nonspecific adsorption enhances signal transduction for sensitive biomarker detection.

Keywords:
acute myocardial infarctionbiosensorfield-effect transistorhybrid phospholipid monolayersensing interface

More Related Videos

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation
13:42

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

12.7K
A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
14:53

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

Published on: September 10, 2014

17.9K

Related Experiment Videos

Last Updated: Apr 11, 2026

Taking Advantage of Reduced Droplet-surface Interaction to Optimize Transport of Bioanalytes in Digital Microfluidics
07:57

Taking Advantage of Reduced Droplet-surface Interaction to Optimize Transport of Bioanalytes in Digital Microfluidics

Published on: November 10, 2014

8.4K
Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation
13:42

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

12.7K
A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
14:53

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

Published on: September 10, 2014

17.9K

Area of Science:

  • Biophysics
  • Materials Science
  • Analytical Chemistry

Background:

  • Charge interactions are critical for signal transduction in biosensors.
  • Biofluid environments cause charge screening and nonspecific adsorption, hindering biosensor performance.
  • Optimizing sensing interfaces is key to overcoming these limitations.

Purpose of the Study:

  • To investigate methods for mitigating charge screening and nonspecific adsorption at sensing interfaces.
  • To develop an interfacial model with adjustable surface charge for improved signal transduction.
  • To enhance the sensitivity of electrical biosensing for biomarker detection.

Main Methods:

  • Constructed a hybrid phospholipid monolayer (HPM) with adjustable surface charge.
  • Utilized molecular dynamics simulations and density-functional theory (DFT) calculations.
  • Doped HPM with unsaturated long-chain molecules to modify interface properties.

Main Results:

  • Regulating surface charge density and interface composition effectively mitigates counterion screening and nonspecific adsorption.
  • Doping HPM with unsaturated molecules enhanced signal transduction capacity.
  • Achieved a highly sensitive detection of myocardial injury biomarkers (MIBs) with a limit of detection (LoD) of 0.92 pg/mL.

Conclusions:

  • An appropriate surface charge density and conjugated molecule doping are crucial for efficient signal transduction in electrical biosensing.
  • The developed sensing interface demonstrates a promising approach for sensitive biomarker detection.
  • Understanding interface composition-performance relationships is vital for advancing biosensor technology.