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Emergence and characterization of new OXA-181 variants in France: OXA-1181, OXA-1201, OXA-1205, OXA-1207, and
Léa Bientz1,2,3,4, Réva Nermont1,4, Cécile Emeraud1,4,5,6
1Faculty of Medicine, Team "Resist," UMR1184 "Immunology of Viral, Auto-Immune, Hematological and Bacterial Diseases (IMVA-HB)," INSERM, Paris-Saclay University, Le Kremlin-Bicêtre, France.
Abstract:
Since 2022, the diversity of OXA-48 variants has increased in France. We analyzed the dissemination of five recent variants (OXA-1181, OXA-1201, OXA-1205, OXA-1207, and OXA-1226) mostly identified on plasmids in high-risk Escherichia coli clones. Three of them (OXA-1181, OXA-1205, and OXA-1207) displayed the same Ser244Trp substitution with no significant impact on the β-lactams hydrolytic profile.IMPORTANCEThis study described the recent emergence of five variants (OXA-1181, OXA-1201, OXA-1205, OXA-1207, and OXA-1226) in France. These variants were mostly identified in Escherichia coli high-risk clones. In addition, most of these new OXA-48 variants (OXA-1181, OXA-1205, and OXA-1207) were derived, interestingly, from OXA-181, OXA-232, and OXA-484 variants due to the apparition of the same S244W substitution, a residue that delimits the active site cavity. Together, these results threaten the dissemination of these OXA-48 variants in the community, highlighting the need for continuous monitoring to better understand their epidemiology and dissemination.
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