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Related Experiment Video

Updated: Apr 11, 2026

Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability
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Exploring the Effects of Remotely Supervised Transcranial Direct Current Stimulation on Motor Outcomes in Multiple

Rehab Aljuhni1, Hind Almotiri1, Alaa Albishi2

  • 1Department of Physical Therapy and Health Rehabilitation, College of Applied Medical Sciences, Majmaah University, Al-Majmaah, Saudi Arabia.

Neurorehabilitation
|April 10, 2026
PubMed
Summary

Remotely supervised transcranial direct current stimulation (RS-tDCS) shows promise for improving gait, balance, and dexterity in multiple sclerosis (MS) patients. Further research is needed to confirm these preliminary findings and establish clinical relevance.

Keywords:
gaitmultiple sclerosisneuromodulationneurorehabilitationtranscranial direct current stimulation

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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Biomedical Engineering

Background:

  • Multiple sclerosis (MS) is a progressive neurological disease causing muscle weakness, reduced walking endurance, and balance issues.
  • These symptoms significantly impair functional independence and quality of life in individuals with MS.
  • Neuromodulation techniques like remotely supervised transcranial direct current stimulation (RS-tDCS) are being explored to enhance neuroplasticity and motor function.

Purpose of the Study:

  • To systematically evaluate the effectiveness, feasibility, and reporting quality of RS-tDCS interventions for motor outcomes in MS.
  • To synthesize current evidence on RS-tDCS applications in MS rehabilitation.
  • To identify methodological gaps and guide future research in decentralized neuromodulation for MS.

Main Methods:

  • A systematic review of literature published between 2015 and 2025 from databases including PubMed, EBSCO, CENTRAL, and Web of Science.
  • Inclusion criteria focused on studies using RS-tDCS to improve motor function or reduce fatigue in the MS population.
  • Data extraction, risk of bias assessment (RoB 2, ROBINS-I), and intervention reporting quality evaluation (TIDieR checklist) were performed by two independent reviewers.

Main Results:

  • Five studies (4 RCTs, 1 non-randomized) involving 370 participants met the inclusion criteria.
  • Positive effects were reported for gait performance, balance, and manual dexterity.
  • Findings regarding functional mobility and fatigue were inconsistent across studies.

Conclusions:

  • RS-tDCS appears to be a feasible neuromodulation technique that may offer benefits in specific motor domains for individuals with MS.
  • The current evidence is preliminary, highlighting the need for more rigorous trials.
  • Future research should focus on establishing the clinical relevance and scalability of RS-tDCS in MS rehabilitation programs.