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Updated: Apr 11, 2026
Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells
Published on: August 2, 2022
Intra-arterial chemoperfusion for breast cancer brain metastases: safety and efficacy
Hamzah Adwan1, Leon V Stein2, Sven Becker3
1Clinic for Radiology and Nuclear Medicine, Goethe University, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. adwan.hamza97@gmail.com.
Background:
This study presents a retrospective analysis of palliative intra-arterial chemoperfusion (IAC) for patients with symptomatic breast cancer brain metastases (BCBM) aiming to investigate the safety and efficacy of the treatment.
Methods:
Thirteen patients with BCBM were treated using a total of 64 IACs, averaging 4.9 per patient. Overall survival (OS) and progression-free survival (PFS) were calculated using the Kaplan-Meier method. Response to IAC was evaluated according to RECIST 1.1.
Results:
There were no treatment-related major complications. A total of three patients (3/11) developed progressive disease. Five (5/11) patients achieved stable disease, two (2/11) partial response, and one (1/11) complete response, resulting in a local tumor control rate of 73% (8/11). Two (2/13) patients could not be evaluated according to RECIST 1.1. The median OS time was 8.2 months (95% CI: 7.7-8.7), and the median PFS time was 7.9 months (95% CI: 0.0-16.3). The mean OS time was 14.5 months (95% CI: 3.4-25.6), and the mean PFS time was 10.6 months (95% CI: 2.6-18.6).
Conclusion:
IAC can be applied as a safe method for palliative patients with BCBM. Further studies are necessary to definitively determine its efficacy.
