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Humoral Immune Responses

Humoral Immune Responses

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Updated: Apr 11, 2026

Author Spotlight: Developing Immunocompetent Organ-on-Chip Models for Infectious Disease Research

Author Spotlight: Developing Immunocompetent Organ-on-Chip Models for Infectious Disease Research

Published on: May 24, 2024

Lymphoid-Tissue-on-Chip Recapitulates Human Antibody Responses In Vitro.

Claudia Teufel^1,2, Anna-Sophie Schlemmer^1,2, Andrea W Eiken¹

¹Department For Microphysiological Systems, Institute of Biomedical Engineering, Eberhard Karls University Tübingen, Tübingen, Germany.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)

|April 10, 2026

Summary

This summary is machine-generated.

This study introduces a novel organ-on-chip model for lymphoid tissue that accurately mimics human adaptive immune responses to vaccines. This advanced model supports long-term culture and reveals detailed antibody production, improving vaccine development.

Keywords:

NAM adaptive immune responses centrifugal microfluidics in vitro lymphoid tissues organ‐on‐chips vaccine research

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Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

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Published on: March 15, 2019

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Author Spotlight: Developing Immunocompetent Organ-on-Chip Models for Infectious Disease Research

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Author Spotlight: Developing a Microfluidic Lung-on-Chip Model for In-Depth Study of Human Immune Response and Infection Mechanisms

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Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Published on: March 15, 2019

Area of Science:

Immunology
Bioengineering
Microfluidics

Background:

Reliable modeling of human adaptive immunity is crucial for vaccine development.
Current non-clinical models have limited predictive value.
Understanding immune responses requires advanced in vitro systems.

Purpose of the Study:

To develop an organ-on-chip model for lymphoid tissue to study adaptive immune responses.
To enable long-term culture of lymphoid tissue for vaccine evaluation.
To assess antigen delivery methods' impact on immune responses.

Main Methods:

Utilized centrifugal microfluidics to create a high-density lymphoid-tissue-on-chip.
Enabled long-term culture of lymphoid tissue, preventing autoactivation.
Induced antigen-specific antibody responses using influenza vaccines.

Main Results:

The lymphoid-tissue-on-chip model demonstrated sustained antigen-specific antibody responses for up to 4 weeks.
Both direct antigen exposure and recruitment of antigen-presenting cells elicited varied antibody responses.
The model successfully mimicked adaptive immune responses to influenza vaccines.

Conclusions:

The organ-on-chip approach provides a reliable platform for studying adaptive immunity and vaccine responses.
This model can evaluate the impact of antigen delivery strategies on immune outcomes.
The lymphoid-tissue-on-chip is a versatile tool for research in immunology, homeostasis, and drug treatment.