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Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders
Published on: April 28, 2023
Copper homeostasis dysregulation and cuproptosis in respiratory diseases
Yusheng Gao1, Xiuping Chen2, Yixin Xu1
1Department of Pulmonary and Critical Care Medicine, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, Changshu, China.
Abstract:
Cuproptosis, a recently identified form of regulated cell death, relies on accumulated copper (Cu) ions and a disrupted mitochondrial respiratory chain. The role of cuproptosis in various diseases, especially respiratory diseases of pulmonary fibrosis, chronic obstructive pulmonary disease, and lung cancer, has been increasingly recognized. This article reviews the dysregulation of Cu homeostasis, cuproptosis's molecular mechanisms, and recent research developments in respiratory diseases, while also exploring potential therapeutic targets and clinical applications.
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