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Updated: Apr 12, 2026

Social Isolation Model: A Noninvasive Rodent Model of Stress and Anxiety
Published on: November 11, 2022
Social Isolation and Loneliness Among U.S. Adults With Self-Reported Hospitalization
Ronald Anguzu1, Mukul Sharda2, Tasmia Amjad2
1Division of Epidemiology & Social Sciences, Institute for Health & Humanity, Medical College of Wisconsin, Milwaukee, Wisconsin.
Over 20% of US adults hospitalized experienced social isolation and nearly 30% reported loneliness. Identifying these individuals during hospitalization is crucial for timely intervention and support.
Area of Science:
- Social epidemiology
- Health services research
- Gerontology
Background:
- Social isolation and loneliness are significant public health concerns, particularly among vulnerable populations.
- Hospitalization can exacerbate or trigger feelings of isolation and loneliness in adults.
Purpose of the Study:
- To determine the prevalence of social isolation and loneliness in U.S. adults who have been hospitalized.
- To identify demographic, socioeconomic, and health-related factors associated with social isolation and loneliness in this population.
Main Methods:
- Analysis of cross-sectional survey data from the 2021 Medical Expenditure Panel Survey (MEPS).
- Inclusion of U.S. adults aged 18 years and older with at least one self-reported hospitalization.
- Application of weighted descriptive analyses and multivariable logistic regression to identify associated factors.
Main Results:
- Prevalence: 22.6% experienced social isolation, 26.6% experienced loneliness.
- Social isolation associated with middle/low income, public insurance, depression, and prior hospitalizations.
- Loneliness associated with marital status (widowed, divorced, separated, never married), depression, and poor perceived health.
- Older adults (45-64 and ≥65 years) and Non-Hispanic Black individuals had lower odds of social isolation.
Conclusions:
- A substantial proportion of hospitalized U.S. adults experience social isolation and loneliness.
- Routine screening for social isolation and loneliness during hospitalization is recommended to identify at-risk individuals.
- Findings highlight the need for targeted interventions to mitigate these issues in hospitalized populations.
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