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Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
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Risk factor profiles and haemodynamic progression in aortic stenosis: a retrospective population-based study
Ming-Sum Lee1, Matt Zhou2, Michael Ho3
1Department of Cardiology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California, USA mingsum.lee@kp.org.
Heart (British Cardiac Society)
|April 10, 2026
Summary
Aortic stenosis (AS) progression varies by severity. Identifying risk factors like anaemia and obesity can help predict rapid deterioration and guide patient monitoring.
Area of Science:
- Cardiology
- Medical Research
- Clinical Epidemiology
Background:
- Aortic stenosis (AS) is a progressive condition with unpredictable progression rates.
- Current surveillance may not identify patients at high risk for rapid hemodynamic decline.
- Real-world data is needed to understand AS progression and identify risk factors.
Purpose of the Study:
- To assess AS progression rates using longitudinal data.
- To identify clinical and echocardiographic factors associated with rapid AS progression.
- To improve risk stratification for AS patient monitoring.
Main Methods:
- Retrospective cohort study of 70,850 adults with at least two transthoracic echocardiograms (TTEs).
- Data collected from an integrated healthcare system between 2011 and 2021.
- Multivariable logistic regression identified predictors of rapid progression (annualized Vmax increase ≥0.3 m/s/year).
Main Results:
- Rapid AS progression observed in 7.8% (aortic sclerosis), 16.4% (mild AS), and 29.8% (moderate AS).
- Factors associated with rapid progression varied by baseline AS severity.
- Older age, anemia, liver disease, renal failure, obesity, and comorbidities were linked to faster progression in earlier stages.
Conclusions:
- AS progression is heterogeneous, influenced by baseline severity and patient risk profiles.
- Integrating clinical and echocardiographic factors can enhance identification of patients needing closer surveillance.
- This approach may facilitate earlier intervention for high-risk individuals.
Keywords:
Aortic Valve Stenosis
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