Related Experiment Video
Updated: Apr 12, 2026
A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage
Published on: July 28, 2018
Chemical Angioplasty Alone versus Chemical and Mechanical Angioplasty for Cerebral Vasospasm after Aneurysmal
Adrien Guenego1, Hamza Adel Salim2,3, Fabio Silvio Taccone4
1From the Department of Diagnostic and Interventional Neuroradiology (A.G., B.L.), Erasme University Hospital, Brussels, Belgium adrienguenego@gmail.com.
Background And Purpose:
Refractory cerebral vasospasm (CV) and delayed cerebral ischemia after aneurysmal SAH are associated with high morbidity and mortality; CV may recur despite intra-arterial chemical treatment and the role of mechanical angioplasty remains unclear. We aim to define the role of mechanical angioplasty in addition to chemical angioplasty.
Materials And Methods:
In a prospective, monocentric, interventional trial, we randomly assigned patients with a refractory CV within the ICAs and an indication for endovascular management to undergo intra-arterial chemical angioplasty (control group) or chemical plus mechanical angioplasty (treatment group). The primary end point was the change of brain perfusion in the dedicated arterial territory measured by the time to drain (TTD) on CT perfusion, before and after treatment.
Results:
A total of 12 patients underwent 44 ICA procedures: 23 were assigned to nimodipine and 21 to nimodipine plus angioplasty. The median percent change in TTD was -14% (interquartile range [IQR], -37 to 9) with nimodipine and -42% (IQR, -54 to -30) with nimodipine plus angioplasty (P = .006). The percent change in arterial diameter was +30% (IQR, 17-40) and +91% (IQR, 68-130), respectively (P < .001). Re-treatment was required in 22 of 23 procedures (96%) in the nimodipine group and in 7 of 21 procedures (33%) in the angioplasty group (P < .001). Complications occurred in 2 of 44 procedures (4.5%), both in the angioplasty group, with no disabling sequelae.
Conclusions:
In this pilot randomized study, the addition of mechanical angioplasty to intra-arterial nimodipine for refractory vasospasm after subarachnoid hemorrhage was associated with greater vessel dilation, improved perfusion, and fewer re-treatments than nimodipine alone, with an acceptable safety profile. Larger, multicenter trials are warranted. (ClinicalTrials.gov number, NCT05268445).
