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Methods for Detecting Cough and Airway Inflammation in Mice
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Neurogenic Cough.

Bryan Renslo1, Kathleen M Tibbetts1

  • 1Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospital, 925 Chestnut Street 6th Floor, Philadelphia, PA 19107, USA.

Otolaryngologic Clinics of North America
|April 10, 2026
PubMed
Summary
This summary is machine-generated.

Neurogenic cough, a condition of laryngeal hypersensitivity, requires excluding other causes. Treatments involve nerve blocks, medications, and emerging P2X3 antagonists for effective relief.

Keywords:
Cough reflexLaryngeal hypersensitivityNeurogenic coughNeuromodulatorsSuperior laryngeal nerve block

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Area of Science:

  • Neurology
  • Otolaryngology

Background:

  • Neurogenic cough is diagnosed by excluding other chronic cough causes.
  • It is characterized by laryngeal hypersensitivity.
  • Vagus nerve injury is a proposed cause.

Purpose of the Study:

  • To review the diagnosis and treatment of neurogenic cough.
  • To discuss current and emerging therapeutic strategies.

Main Methods:

  • Systematic exclusion of common chronic cough etiologies.
  • Review of proposed pathophysiological mechanisms.
  • Summary of established and novel treatment options.

Main Results:

  • Diagnosis relies on excluding other conditions and identifying laryngeal hypersensitivity.
  • Vagus nerve injury is implicated in the pathophysiology.
  • Treatments include neuromodulators, behavioral therapy, and superior laryngeal nerve blocks.

Conclusions:

  • Neurogenic cough management requires a stepwise exclusion approach.
  • Established treatments offer symptomatic relief.
  • P2X3 antagonists represent a promising targeted therapy for the future.