Immunoferroptosis: ferroptosis meets tumor immunity and immunotherapy

Ferroptosis, a regulated form of cell death driven by iron-dependent lipid peroxidation, has attracted considerable attention in tumor biology and cancer therapy. Beyond its intrinsic role in tumor suppression, ferroptosis greatly influences the tumor immune microenvironment. Ferroptotic tumor cells release damage-associated molecular patterns, oxidized lipid mediators, and nucleic acids, which can either activate or suppress antitumor immunity. Conversely, immune cells modulate tumor cell sensitivity to ferroptosis through the secretion of cytokines and metabolites. In this review, we summarize the current understanding of the interplay between ferroptosis and tumor immunity. Targeting ferroptosis may offer broad opportunities to enhance tumor immunotherapy.