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Base editing restores CDKL5 expression and rescues neuronal deficits in a patient-derived model of CDKL5 deficiency

Yue Chai1,2, Yao Zhu1, Jiayi Zhu3

  • 1School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, SAR, China.

Scientific Reports
|April 10, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Adenine base editing (ABE)CDKL5 deficiency disorderCyclin-dependent kinase like 5 (CDKL5)Gene correctionNeurodevelopmental disorderiPSCs

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