Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Connectome simulations identify a central pattern generator circuit for fly walking.

bioRxiv : the preprint server for biology·2026
Same author

StrIPETrack: a real-time, ROI-flexible tracking platform for high-throughput zebrafish behavior.

Biology open·2026
Same author

Deep neural networks to register and annotate cells in moving and deforming nervous systems.

eLife·2026
Same author

<i>StrIPETrack</i>: a real-time, ROI-flexible tracking platform for high-throughput zebrafish behavior.

bioRxiv : the preprint server for biology·2026
Same author

Deep Neural Networks to Register and Annotate Cells in Moving and Deforming Nervous Systems.

bioRxiv : the preprint server for biology·2025
Same author

Nucleosome spacing can fine-tune higher-order chromatin assembly.

Nature communications·2025

Related Experiment Video

Updated: Apr 12, 2026

Tracking and Quantifying Developmental Processes in C. elegans Using Open-source Tools
10:41

Tracking and Quantifying Developmental Processes in C. elegans Using Open-source Tools

Published on: December 16, 2015

9.4K

Neural sequences underlying directed turning in Caenorhabditis elegans.

Talya S Kramer1,2, Flossie K Wan1, Sarah M Pugliese1

  • 1Howard Hughes Medical Institute, Picower Institute for Learning and Memory, Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.

Nature Neuroscience
|April 10, 2026
PubMed
Summary

Scientists uncovered how the nematode C. elegans uses sequential neural activity to navigate using smell. Tyramine, a neuromodulator, coordinates these brain dynamics, linking sensory cues to motor actions for effective movement.

More Related Videos

Fine Adjustment of Caenorhabditis elegans Orientation on Channeled Agar Pads for Imaging Neuroregeneration
05:12

Fine Adjustment of Caenorhabditis elegans Orientation on Channeled Agar Pads for Imaging Neuroregeneration

Published on: January 31, 2025

901
Visualizing Neuroblast Cytokinesis During C. elegans Embryogenesis
09:52

Visualizing Neuroblast Cytokinesis During C. elegans Embryogenesis

Published on: March 12, 2014

12.5K

Related Experiment Videos

Last Updated: Apr 12, 2026

Tracking and Quantifying Developmental Processes in C. elegans Using Open-source Tools
10:41

Tracking and Quantifying Developmental Processes in C. elegans Using Open-source Tools

Published on: December 16, 2015

9.4K
Fine Adjustment of Caenorhabditis elegans Orientation on Channeled Agar Pads for Imaging Neuroregeneration
05:12

Fine Adjustment of Caenorhabditis elegans Orientation on Channeled Agar Pads for Imaging Neuroregeneration

Published on: January 31, 2025

901
Visualizing Neuroblast Cytokinesis During C. elegans Embryogenesis
09:52

Visualizing Neuroblast Cytokinesis During C. elegans Embryogenesis

Published on: March 12, 2014

12.5K

Area of Science:

  • Neuroscience
  • Behavioral Biology
  • Computational Neuroscience

Background:

  • Complex behaviors like navigation depend on sequenced motor outputs.
  • The brain circuits integrating sensory signals for motor sequences are not well understood.

Purpose of the Study:

  • To characterize the neural circuit architecture controlling Caenorhabditis elegans olfactory navigation.
  • To understand the neural basis of error-correcting turns during navigation.

Main Methods:

  • Whole-brain calcium imaging in C. elegans.
  • Cell-specific genetic perturbations.
  • Analysis of neural and motor sequences during olfactory navigation.

Main Results:

  • Identified sequential neural activity underlying error-correcting turns.
  • Specific neurons responded to olfactory cues, predicted turn direction, and drove movement.
  • The neuromodulator tyramine was found to coordinate these sequential brain dynamics.

Conclusions:

  • Neuromodulation, specifically tyramine, acts on a defined neural architecture to link sensory cues to motor actions in C. elegans.
  • This study provides insights into the sensorimotor control of navigation.