Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

125
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
125
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.2K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.8K
1.8K
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

2.9K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.9K
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

130
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
130

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Decoy oligonucleotide technology in cancer therapy: molecular mechanisms, challenges, and translational potential.

Medical oncology (Northwood, London, England)·2026
Same author

Development and Characterization of a Cold Cream with Antioxidant Properties from <i>Bougainvillea</i> Extract.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Exploring the Potential of Calebin-A in Targeting Obesity-Related Genes and Pathways.

Journal of cellular and molecular medicine·2026
Same author

Leaflet Perforation as a Complication of Tricuspid Transcatheter Edge-to-Edge Repair.

JACC. Case reports·2026
Same author

Superoxide Dismutase-Centered Modulation by Curcumin in Cardiovascular Diseases: Mechanistic Insights and Translational Implications.

Journal of cellular and molecular medicine·2026
Same author

Curcumin-Dragon's blood-chitosan nanosuspension for dual forensic detection.

Scientific reports·2026

Related Experiment Video

Updated: Apr 12, 2026

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.6K

Recent Advances in Surface-Engineered Polymeric Nanoparticles for Targeted Paclitaxel Delivery in Breast Cancer

Mahak Fatima1, Fahad AlQahtani2, Prashant Kesharwani3,4

  • 1Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.

AAPS Pharmscitech
|April 10, 2026
PubMed
Summary

Surface-functionalized polymeric nanoparticles enhance paclitaxel (PTX) delivery for breast cancer treatment. These targeted nanoparticles improve drug efficacy and reduce toxicity, paving the way for clinical translation.

Keywords:
breast cancer therapypaclitaxelpolymeric nanoparticlessurface engineeringtargeted drug delivery

More Related Videos

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.2K
Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

16.8K

Related Experiment Videos

Last Updated: Apr 12, 2026

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.6K
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.2K
Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

16.8K

Area of Science:

  • Oncology
  • Nanotechnology
  • Drug Delivery

Background:

  • Breast cancer is a leading cause of cancer mortality globally.
  • Paclitaxel (PTX) is a key chemotherapy agent but suffers from poor solubility and toxicity.
  • Polymeric nanoparticles offer a strategy to improve PTX delivery and efficacy.

Purpose of the Study:

  • To review recent advances in surface-functionalized polymeric nanoparticles for targeted paclitaxel delivery in breast cancer.
  • To consolidate the translational relevance and design considerations for next-generation PTX nanocarriers.

Main Methods:

  • Focus on ligand-functionalized polymeric nanoparticles for active targeting of breast cancer cells.
  • Integration of biological rationale, receptor specificity, and translational relevance.
  • Discussion of surface engineering with ligands like folic acid, hyaluronic acid, aptamers, and peptides.

Main Results:

  • Surface-engineered nanoparticles target overexpressed receptors (CD44, HER2, folate receptors) on cancer cells.
  • Ligand-receptor interactions facilitate receptor-mediated endocytosis for enhanced intracellular drug delivery.
  • Minimized systemic toxicity and extended drug release are achieved.

Conclusions:

  • Surface-modified, PTX-loaded polymeric nanoparticles represent a significant advancement in precision breast cancer drug delivery.
  • These nanocarriers address key treatment challenges, including poor solubility and systemic toxicity.
  • The development shows promise for clinical translation in breast cancer therapy.