Related Experiment Video

Updated: Apr 12, 2026

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts
09:21

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts

Published on: February 23, 2024

1.7K

Finding ferritin footprints in 5-fluorouracil-induced cardiotoxicity

Grace M Ferri1, Manuel Urina-Jassir2, Alexander V Stanisic2

  • 1Section of General Internal Medicine, Department of Medicine, Boston Medical Center, Boston, MA, USA. gferri@bu.edu.

Cardio-Oncology (London, England)
|April 10, 2026
PubMed
Summary

Elevated ferritin levels (≥100 ng/mL) in patients receiving 5-fluorouracil (5-FU) chemotherapy may indicate potential cardiotoxicity and treatment failure. Routine iron studies are recommended alongside echocardiography for monitoring.

Keywords:
CardiotoxicityChemotherapyCoronary artery diseaseFluoropyrimidinesGastrointestinal malignancies

More Related Videos

Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation08:03

Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation

Published on: October 20, 2022

2.3K
A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo05:14

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

5.5K

Related Concept Videos

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
69