Influenza Vaccination Responses in Disabled Stroke Patients: A Single-Center Prospective Observational Study

Area of Science:

• Immunology
• Neurology
• Vaccinology

Background:

• Ischemic stroke patients may have altered immune responses.
• Influenza vaccination is crucial for preventing infections in vulnerable populations.

Purpose of the Study:

• To assess the immunological response to influenza vaccination in ischemic stroke patients.
• To evaluate influenza infection incidence, severity, and vaccination side effects.

Main Methods:

• Prospective observational study (2023-2024) with 161 participants.
• Inactivated trivalent influenza vaccine administered.
• Seroprotection and seroconversion measured via hemagglutination inhibition tests.

Main Results:

• Functionally independent patients had higher antibody titers against A/Sydney (H1N1) post-vaccination.
• Seroconversion rates were higher in controls compared to functionally independent or dependent groups.
• Overall influenza incidence was 6.2 cases per 100 person-years; no serious adverse events.

Conclusions:

• Seroprotection rates were higher in functionally independent ischemic stroke patients.
• Functionally dependent patients may benefit from modified influenza vaccination approaches for improved immunity.