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Updated: May 19, 2026
09:45
Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015
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Synergistic Sunlight-Activated Photodynamic and Near-Infrared-Induced Mild Photothermal Therapy for Infected Wound
Yihao Sun1,2, Liangrui He3,4, Zhijun Shen1,2
1Foot & Ankle Surgery, Department of Orthopaedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|April 11, 2026
Summary
A novel nanoplatform combines photodynamic and mild thermal therapies to combat drug-resistant bacterial infections and promote wound healing by reprogramming immune cells. This approach enhances tissue regeneration and reduces inflammation for effective infected wound repair.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Regenerative Medicine
Background:
- Bacterial infections and antibiotic resistance hinder wound healing.
- Developing multifunctional platforms for combined therapies is crucial.
Purpose of the Study:
- To develop a multifunctional nanoplatform for infected wound repair.
- To integrate photodynamic therapy (PDT), photothermal therapy (PTT), and ion release for enhanced antibacterial and regenerative effects.
Main Methods:
- Fabrication of a Bi2WO6:Yb,Er@CuS@CS nanoplatform.
- Evaluation of antibacterial efficacy against MRSA and E. coli.
- Assessment of NIR-triggered mild PTT for macrophage polarization.
- In vivo studies on MRSA-infected wound models.
Main Results:
- The nanoplatform demonstrated >99% antibacterial efficacy and biofilm disruption.
- NIR-induced mild PTT reprogrammed M1 macrophages to M2 phenotype, downregulating key inflammatory pathways.
- Accelerated wound healing, enhanced angiogenesis, and collagen deposition were observed in vivo.
- Minimal systemic toxicity was noted.
Conclusions:
- The developed nanoplatform offers a promising strategy for infected wound healing.
- Combining PDT, mild PTT, and immunomodulation effectively addresses bacterial resistance and promotes tissue regeneration.
- This sunlight/NIR-activated approach bridges antibacterial treatment and immune-regulated tissue repair.
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