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Updated: Apr 13, 2026

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
Cobalt-Catalyzed Hydrogen-Bond-Promoted Tandem Cyclization and Oxygen Migration: Access to Sterically Congested Fused
Yutian Zhou1, Jian-Dong Zhang1, Jiacheng Xu1
1Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, P. R. China.
Abstract:
A cobalt-catalyzed, hydrogen-bond-promoted strategy for the synthesis of sterically congested fused tetrahydro-β-carbolines bearing quaternary carbon centers is reported. This transformation employs tryptamine-derived isocyanides and anthranils as readily available building blocks and proceeds through a tandem oxygen migration and cyclization process with high atom economy. Moderate to good yields are obtained for structurally diverse products. Water plays a crucial role by providing a hydrogen-bonding environment and serving as a proton shuttle to facilitate the reaction process, which is supported by isotope-labeling experiments and DFT calculations.
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