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Q&A with Christopher Morrison and Matthew Potthoff.

Christopher D Morrison, Matthew J Potthoff

    Cell Reports
    |April 11, 2026
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    Summary
    This summary is machine-generated.

    Fibroblast growth factor 21 (FGF21) regulates feeding and energy balance by acting on the brain. New research identifies a specific hindbrain circuit crucial for mediating these FGF21 effects.

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    Area of Science:

    • Neuroendocrinology
    • Metabolic regulation
    • Hormonal signaling

    Background:

    • Fibroblast growth factor 21 (FGF21) is a hormone produced by the liver.
    • FGF21 plays a role in metabolic adaptations to fasting and diet.
    • The specific brain mechanisms underlying FGF21 function are not fully understood.

    Purpose of the Study:

    • To identify the brain regions and neural circuits mediating FGF21's effects.
    • To understand how FGF21 influences feeding behavior and energy expenditure.
    • To elucidate the central nervous system pathways involved in FGF21 signaling.

    Main Methods:

    • Investigated the role of FGF21 in the central nervous system.
    • Utilized neurobiological approaches to map FGF21-responsive circuits.
    • Examined the impact of FGF21 on feeding and energy expenditure in vivo.

    Main Results:

    • Identified a specific hindbrain circuit that mediates FGF21's actions.
    • Demonstrated that this hindbrain circuit is critical for regulating feeding behavior.
    • Showed that FGF21 signaling in the hindbrain influences energy expenditure.

    Conclusions:

    • The hindbrain contains key neural circuits controlling FGF21's metabolic and behavioral effects.
    • Targeting these hindbrain circuits may offer new strategies for metabolic disease treatment.
    • This work clarifies the central neural pathways of FGF21 action.