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Related Experiment Video

Updated: Apr 13, 2026

In Vivo Imaging of Neural Activity in Unanesthetized Drosophila Adult Flies

In Vivo Imaging of Neural Activity in Unanesthetized Drosophila Adult Flies

Published on: June 20, 2025

Individualized decision-making driven by long-term memory retrieval in Drosophila.

Kuan-Lin Feng¹, Ming-Chin Wu¹, Ching-Che Charng¹

¹Brain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan.

|April 11, 2026

Summary

This summary is machine-generated.

Decision-making varies due to memory accessibility. In fruit flies, long-term memory shows more variability than short-term memory, linked to how memory guides actions.

Keywords:

CP: Neuroscience decision-making individuality long-term memory neural circuit retrieval

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Last Updated: Apr 13, 2026

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Area of Science:

Neuroscience
Animal Behavior
Memory Research

Background:

Decision-making processes are influenced by memory accessibility, leading to variable outcomes.
The neural underpinnings of memory retrieval's role in decision-making are not fully understood.
Individual differences in decision-making are observed even with identical information.

Purpose of the Study:

To investigate the neural mechanisms of memory retrieval in decision-making.
To compare the variability of short-term versus long-term memory in guiding behavior.
To explore how memory influences navigation and individualized choices.

Main Methods:

Utilizing Drosophila melanogaster as a model organism.
Employing optogenetic techniques to photoactivate memory-critical mushroom body output neurons.
Analyzing individualized presynaptic terminal asymmetry and turning behaviors.
Correlating memory-driven avoidance behavior adoptability with long-term memory performance.

Main Results:

Aversive olfactory long-term memory in Drosophila displays greater variability compared to short-term memory.
Variability in long-term memory performance correlates with the trial-by-trial adoption of memory-guided avoidance actions.
Individualized presynaptic terminal asymmetry in mushroom body output neurons is linked to idiosyncratic turning behaviors.
Downstream circuits connecting memory to navigation were mapped.

Conclusions:

The study reveals that memory retrieval significantly shapes individualized decision-making processes.
Differences in the adoption of memory-guided actions contribute to the variability observed in long-term memory.
Mapping neural circuits provides insights into how memory influences navigation and behavioral choices.