MOF-based nanozymes: Rational design and biomedical applications

Area of Science:

• Materials Science
• Biotechnology
• Catalysis

Background:

• Nanozymes are nanomaterials mimicking natural enzyme catalytic activities.
• Metal–organic frameworks (MOFs) are a significant subclass of nanozymes due to their unique nanoporous structure and defined active sites.

Purpose of the Study:

• To systematically review recent advancements in MOF-based nanozymes.
• To describe the diverse catalytic activities of MOFs and strategies for enhancing their performance.
• To highlight therapeutic applications of MOF-based nanozymes in disease treatment.

Main Methods:

• Comprehensive review of existing literature on MOF-based nanozymes.
• Analysis of MOF structures, catalytic mechanisms, and activity regulation strategies.
• Examination of therapeutic applications in cancer, inflammatory diseases, and infections.

Main Results:

• MOF-based nanozymes exhibit well-defined active sites that mimic natural enzymes.
• These nanozymes display exceptional catalytic activity and substrate selectivity.
• Microenvironmentally responsive MOF-based nanozymes show promise in multimodal synergistic therapies.

Conclusions:

• MOF-based nanozymes offer a powerful platform for advanced biotechnology and disease treatment.
• Rational design and activity regulation are key to maximizing their therapeutic potential.
• Further research into challenges and prospects will drive innovation in MOF nanozyme applications.