Related Experiment Video
Updated: Apr 13, 2026

Predictive Immune Modeling of Solid Tumors
Published on: February 25, 2020
Novel immunotherapy response predictor based on blood Temra cell signature
1Clinical Trial Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
None:
Dong et al. revealed that circulating CX3CR1+ terminally differentiated effector memory (Temra) cells are key predictors of immunotherapy response. A 20-gene Temra transcriptional signature that stratifies responders from non-responders was developed, achieving an area under the curve (AUC) of 0.834 in a prospective multi-center cohort. The study establishes a blood-based biomarker that captures the pre-existing functional state of systemic immunity, offering a translational tool to guide immunotherapy.
Related Concept Videos
Tumor Immunotherapy
Cells of the Adaptive Immune Response
Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

