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Depressive Disorders: Etiology01:27

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Association Between Myocardial Infarction and Depression: Bidirectional Links and Shared Risk Pathways-A Systematic

Konstantina-Maria Panoutsopoulou1, Nikolaos-Stefanos Bastas1, Dimitrios Tsartsalis1,2

  • 1Scientific Laboratory of Psychology and Person-Centered Care, Department of Nursing, School of Health Sciences, University of Ioannina, Ioannina, Greece.

European Journal of Preventive Cardiology
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PubMed
Summary

Myocardial infarction (MI) and depression share a two-way link, increasing the risk for each other. This connection is influenced by demographics and common health issues, highlighting the need for integrated care.

Keywords:
AntidepressantsCardiovascular riskComorbidityDepressionMeta-analysisMyocardial infarction

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Area of Science:

  • Cardiology
  • Psychiatry
  • Epidemiology

Background:

  • Myocardial infarction (MI) and depression are significant public health concerns.
  • The bidirectional relationship between MI and depression is not fully understood.
  • Shared risk factors and comorbidities may underlie their co-occurrence.

Purpose of the Study:

  • To investigate the bidirectional association between MI and depression.
  • To identify shared comorbidities and cardiovascular risk factors contributing to their co-occurrence.

Main Methods:

  • Systematic literature search of PubMed, Embase, and PsycINFO.
  • Meta-analysis of prospective cohort and longitudinal studies using random-effects models.
  • Assessment of study quality using the Newcastle-Ottawa Scale and subgroup/sensitivity analyses.

Main Results:

  • MI was associated with a 41% increased risk of subsequent depression (HR 1.41).
  • Depression was associated with a 42% increased risk of incident MI (HR 1.42).
  • Associations varied by age and sex; tricyclic antidepressants, but not SSRIs, were linked to increased MI risk.

Conclusions:

  • MI and depression exhibit a bidirectional relationship, with each condition increasing the risk for the other.
  • Demographic variations and shared cardiometabolic/mental comorbidities are evident.
  • Integrated cardiovascular and mental health assessments are crucial, though findings require cautious interpretation due to limited evidence.