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Updated: Apr 14, 2026
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Cost-effectiveness of an artificial intelligence predictive model for guiding androgen deprivation therapy in
P Travis Courtney1, Ya-Chen Tina Shih1, Albert J Chang1
1Department of Radiation Oncology, University of California, Los Angeles, CA, United States.
Abstract:
The ArteraAI Prostate Test (ArteraAI Inc.) is the first predictive biomarker for the benefit of adding short-term androgen deprivation therapy (ADT) to radiotherapy for intermediate-risk prostate cancer. We evaluated the cost-effectiveness of ArteraAI to guide short-term ADT using a Markov model simulating 15-year outcomes for 71-year-old patients with intermediate-risk prostate cancer receiving radiotherapy using NRG/RTOG 9408 data on which ArteraAI was validated. Three strategies were compared: (1) all patients receive ADT (ADT-for-all), (2) only patients with unfavorable intermediate-risk prostate cancer receive ADT (National Comprehensive Cancer Network [NCCN]), and (3) only ArteraAI-positive patients receive ADT (ArteraAI). Costs and utilities obtained from Medicare claims and published literature were used to calculate incremental cost-effectiveness ratios. A willingness-to-pay threshold of $100 000/quality-adjusted life year (QALY) was chosen. The ADT-for-all strategy was dominated by the NCCN strategy. Compared with the NCCN strategy, the ArteraAI strategy lowered costs by $12 296 and improved effectiveness by 0.01 QALYs making it dominant.
