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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.7K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

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Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
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Related Experiment Video

Updated: Apr 14, 2026

Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer
08:37

Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer

Published on: November 15, 2024

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Fueling asthma inflammation via bioenergetic metabolic reprogramming.

Anny Mulya1, Allison J Janocha1, Michael V Novotny1

  • 1Department of Inflammation and Immunity , Cleveland Clinic Research, Cleveland, OH, USA.

Redox Biology
|April 12, 2026
PubMed
Summary

Asthma involves metabolic changes, with altered bioenergetic networks and increased lipid metabolism pathways. This study reveals a unique bioenergetic phenotype in asthma patients, impacting cellular energy production and utilization.

Keywords:
AsthmaBioenergetic-metabolite networkBioenergeticsMetabolomics

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Metabolic Characterization of Polarized M1 and M2 Bone Marrow-derived Macrophages Using Real-time Extracellular Flux Analysis
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Related Experiment Videos

Last Updated: Apr 14, 2026

Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer
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Metabolic Characterization of Polarized M1 and M2 Bone Marrow-derived Macrophages Using Real-time Extracellular Flux Analysis
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Area of Science:

  • Biochemistry
  • Systems Biology
  • Metabolomics

Background:

  • Metabolic and bioenergetic abnormalities are linked to asthma.
  • The precise mechanisms connecting these disruptions to asthma pathophysiology are not fully understood.

Purpose of the Study:

  • To investigate the hypothesis that asthma arises from altered connectivity within metabolic networks.
  • To map the bioenergetic-metabolite interactome in asthma using a systems-level approach.

Main Methods:

  • Integrated platelet bioenergetic profiling and plasma metabolomics.
  • Analyzed fasting plasma metabolites and platelet bioenergetics in individuals with asthma (n=40) and healthy controls (n=18).
  • Studied primary human airway smooth muscle cells.

Main Results:

  • Identified 119 altered metabolites, with adenosine derivatives correlating with inflammation and lung function.
  • Observed reduced ATP-linked oxygen consumption and greater bioenergetic reserve capacity in asthma.
  • Found decreased mitochondrial glucose utilization in asthma airway smooth muscle cells.
  • Revealed a restructured metabolic network in asthma with fewer connections and new clusters enriched in lipid metabolism.

Conclusions:

  • Asthma exhibits a distinct bioenergetic phenotype characterized by increased oxidative reserve capacity.
  • Reduced mitochondrial glucose utilization and a shift towards lipid metabolism pathways are key features of asthma.
  • The study highlights a restructured bioenergetic-metabolite network in asthma, offering new insights into disease mechanisms.