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Updated: Apr 14, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Picpuranes A-E, structurally diverse diterpenoids from Picea purpurea
Dai-Lin Tang1, Zhan-Tao Zhao1, Min Hu1
1School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China.
Abstract:
Phytochemical investigation on the cones of Picea purpurea led to the isolation of four previously undescribed abietane diterpenoids (1-4) and one new isopimarane diterpenoid (5), alongside 23 known abietane analogues (6-28). Compounds 1 and 2 represent two unusual 19-nor-abietanes, while 3 features a rare naturally occurring 13,14-seco-abietane skeleton. Their structures were established by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. All isolates were evaluated for the inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophages. The results showed that 1 and 2 exhibited moderate inhibition of NO production.
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