Related Experiment Video

Updated: Apr 14, 2026

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
10:09

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence

Published on: January 7, 2019

8.9K

The tumor suppressive role of KEAP1: Underlying mechanisms and therapeutic implications

Ziyu Zhang1, Xiangting Jin2, Junhong Chen1

  • 1Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, First Hospital of Jilin University, Changchun, Jilin Province, China.

Biochimica Et Biophysica Acta. Molecular Basis of Disease
|April 12, 2026
PubMed

Insights

Kelch-like ECH-associated protein 1 (KEAP1) mutations promote cancer by activating NRF2. Understanding KEAP1

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Kelch-like ECH-associated protein 1 (KEAP1) is an adaptor protein regulating the degradation of transcription factor NF-E2-related factor 2 (NRF2).
  • Genetic alterations in KEAP1 are common in various cancers, leading to NRF2 pathway activation.
  • This activation promotes tumor development, therapeutic resistance, and immune evasion.

Purpose of the Study:

  • To review the molecular mechanisms of KEAP1's tumor-suppressive function.
  • To detail the consequences of cancer-associated KEAP1 mutations.
  • To explore KEAP1 as a prognostic biomarker and therapeutic target.

Main Methods:

  • Systematic review of scientific literature.
  • Analysis of molecular mechanisms.
  • Evaluation of clinical implications and therapeutic strategies.

Main Results:

  • KEAP1 aberrations lead to constitutive NRF2 activation, driving tumorigenesis.
  • KEAP1 mutations are linked to therapeutic resistance and immune evasion.
  • KEAP1 alterations have prognostic significance in cancer patients.

Conclusions:

  • KEAP1 plays a critical role in cancer suppression through NRF2 regulation.
  • Targeting the KEAP1-NRF2 axis offers potential therapeutic avenues.
  • KEAP1 alterations are important biomarkers for cancer prognosis and treatment.
Keywords:
KEAP1MutationsOxidative stressPTMTargeted therapyTumorigenesis

More Related Videos

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies09:29

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Published on: September 30, 2016

14.6K
Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

18.9K

Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
8.5K
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
6.4K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
8.0K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.2K
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
9.3K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.4K