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Association Between Ventricular-Arterial Coupling and C-Reactive Protein in Patients at Risk for Heart Failure.

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Circulation Journal : Official Journal of the Japanese Circulation Society
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Summary
This summary is machine-generated.

High-sensitivity C-reactive protein (hs-CRP) is linked to ventricular-arterial coupling (VAC) in hypertensive patients at risk for heart failure. This association remained significant after adjusting for various cardiovascular risk factors.

Keywords:
C-reactive proteinHeart failureHypertensionVentricular–arterial coupling

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Area of Science:

  • Cardiology
  • Biomedical Engineering

Background:

  • Ventricular-arterial coupling (VAC) and C-reactive protein (CRP) are implicated in heart failure (HF) pathogenesis.
  • The relationship between VAC and CRP in HF-at-risk populations is not well understood.

Purpose of the Study:

  • To investigate the association between high-sensitivity C-reactive protein (hs-CRP) and ventricular-arterial coupling (VAC) in hypertensive patients.
  • To determine if hs-CRP is an independent predictor of VAC in individuals at risk for heart failure.

Main Methods:

  • Ventricular-arterial coupling (VAC) was evaluated using the arterial elastance (Ea) to left ventricular end-systolic elastance (Ees) ratio (Ea/Ees).
  • The noninvasive single-beat method was employed in 112 hypertensive patients.
  • High-sensitivity C-reactive protein (hs-CRP) levels were analyzed in both log-transformed and categorical forms.

Main Results:

  • Univariate analysis revealed associations between both log-transformed and categorical hs-CRP and Ea/Ees.
  • Categorical hs-CRP demonstrated an independent association with Ea/Ees (β=0.27, P=0.003).
  • This independence was maintained after adjusting for atherosclerotic risk factors, cardiac function, and vascular function.

Conclusions:

  • High-sensitivity C-reactive protein (hs-CRP) is independently associated with ventricular-arterial coupling (VAC) as assessed by the Ea/Ees ratio.
  • These findings suggest hs-CRP may play a role in the mechanical alterations of the heart and vasculature in patients at risk of heart failure.