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Related Experiment Video

Updated: Apr 14, 2026

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A Synthetic Form of Cannabinoid Does Not Decrease Opioid Use After Total Knee Arthroplasty: A Prospective,

Jason M Jennings1, Douglas A Dennis2, Todd M Miner3

  • 1Colorado Joint Replacement, Porter Adventist Hospital, Denver, Colorado; Department of Mechanical and Materials Engineering, University of Denver, Denver, Colorado; Affiliate Assistant Professor, Department of Physical Therapy, University of Delaware, Newark, Delaware.

The Journal of Arthroplasty
|April 12, 2026
PubMed
Summary
This summary is machine-generated.

This study found that synthetic delta-9-tetrahydrocannabinol (sTHC) did not reduce opioid use in patients after total knee arthroplasty (TKA). Dronabinol showed no significant benefit for pain management or recovery in TKA patients.

Keywords:
cannabisopioid consumptionpain managementpatient reported outcomestotal knee arthroplasty

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Area of Science:

  • Orthopaedic Surgery
  • Pain Management
  • Pharmacology

Background:

  • Cannabis use is rising among patients undergoing total knee arthroplasty (TKA).
  • The efficacy of cannabis for pain management post-TKA lacks prospective randomized study data.
  • Synthetic delta-9-tetrahydrocannabinol (sTHC), dronabinol, is being considered for pain relief.

Purpose of the Study:

  • To determine if dronabinol decreases opioid consumption after TKA.
  • To evaluate the impact of sTHC on pain, sleep, nausea, and functional outcomes post-TKA.

Main Methods:

  • A prospective randomized, double-blind study involving 163 TKA patients.
  • Patients received either dronabinol (2.5 mg twice daily) or a placebo as an adjunct to standard pain management.
  • Primary outcome was opioid morphine milligram equivalents (MME) at two weeks; secondary outcomes included pain, sleep, and patient-reported measures.

Main Results:

  • No significant difference in in-hospital or two-week MME between the dronabinol and placebo groups.
  • No differences observed in self-reported pain, sleep scores, or nausea/vomiting at two and four weeks.
  • Patient-reported outcomes at six weeks and complications showed no significant group differences.

Conclusions:

  • Synthetic delta-9-tetrahydrocannabinol (dronabinol) does not reduce opioid intake following primary TKA.
  • Current evidence suggests sTHC offers no significant benefit for pain management or recovery in TKA patients.
  • Further research may be needed to explore other cannabinoids or patient populations.