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Related Experiment Video

Updated: Apr 14, 2026

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Cognitive performance after stroke at a young age from a brain network perspective.

Hao Li1, Mijntje M I Schellekens1, Vitória Piai2

  • 1Department of Neurology, Radboudumc Research Institute for Medical Innovation, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, PO Box 9101, Nijmegen, 6500, HB, The Netherlands.

Trends in Neurosciences
|April 12, 2026
PubMed
Summary

Cognitive impairment and aphasia affect many young stroke survivors. This review examines cognitive recovery, brain network disruptions, and rehabilitation strategies for optimizing outcomes in young adults post-stroke.

Keywords:
aphasiabrain connectivitycognitive rehabilitationresiliencewhite matteryoung stroke

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Area of Science:

  • Neuroscience
  • Neurology
  • Rehabilitation Medicine

Background:

  • Cognitive impairment affects nearly 50% of young stroke survivors.
  • Aphasia impacts approximately 25% of this population.
  • Understanding post-stroke cognitive trajectories is crucial.

Purpose of the Study:

  • To review the temporal course of cognitive performance in young adults after stroke.
  • To examine how focal lesions disrupt brain networks and affect cognition.
  • To discuss brain resilience and cognitive rehabilitation strategies.

Main Methods:

  • Literature review of studies on young stroke survivors.
  • Analysis of temporal cognitive changes post-stroke.
  • Examination of neuroimaging findings on brain network disruption.

Main Results:

  • Cognitive impairment is a significant issue for young stroke survivors.
  • Focal lesions disrupt local and global brain networks, impacting cognitive functions.
  • Evidence for cognitive rehabilitation interventions is reviewed.

Conclusions:

  • Network-informed and individualized approaches are essential for optimizing outcomes.
  • Further age-specific research is needed for young stroke patients.
  • Enhancing brain resilience may improve long-term functional recovery.