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Updated: Apr 14, 2026

Study of Protein-protein Interactions in Autophagy Research
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CORO1C (coronin 1C) promotes autophagosome formation by coordinating branched actin network dynamics

Guozhong Zhang1,2, Ningqing Yu1,2, Yi Sun1,2

  • 1State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Autophagy
|April 13, 2026
PubMed

Insights

Coronin 1C (CORO1C) is a newly found regulator of autophagy, essential for cellular homeostasis. Loss of CORO1C impairs autophagy, leading to starvation sensitivity and memory deficits in mice.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • Macroautophagy/autophagy is crucial for cellular homeostasis and clearing cytotoxic material.
  • The precise mechanisms regulating autophagy are not fully understood.
  • Actin cytoskeleton dynamics are increasingly recognized as important in cellular processes.

Purpose of the Study:

  • To identify novel regulators of mammalian autophagy.
  • To investigate the role of actin-binding proteins in autophagy.
  • To elucidate the function of Coronin 1C (CORO1C) in autophagy and cellular processes.

Main Methods:

  • Genome-wide loss-of-function screen using a mouse haploid ESC mutant library.
  • Analysis of protein interactions between CORO1C and the ACTR2/ARP2-ACTR3/ARP3 complex.
  • Phenotypic analysis of coro1c knockout mice, including starvation response and cognitive function.

Main Results:

  • CORO1C was identified as a novel regulator of mammalian autophagy.
  • CORO1C is essential for branched actin network assembly and autophagosome formation.
  • coro1c knockout mice exhibit starvation lethality, autophagy deficiency, and spatial learning memory impairment.

Conclusions:

  • CORO1C plays a critical role in promoting branched actin network formation, vital for autophagy.
  • CORO1C is indispensable for the structural integrity of autophagosomes and the overall autophagic process.
  • Dysregulation of CORO1C impacts cellular homeostasis, organismal survival, and cognitive function.
Keywords:
ARP2/3 complexSQSTM1/p62 body formationautophagybranched actin networkcoronin 1Cgenetic screen

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