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Updated: Apr 14, 2026
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Frailty and genetics: linking molecular aging to clinical vulnerability
Jhuliana Castillo1, Natalia García2, Fernando Gómez1
1Research Group on Geriatrics and Gerontology, Faculty of Health Sciences, Universidad de Caldas, Manizales, Colombia.
Summary
This review explores the genetic underpinnings of frailty, a complex geriatric syndrome. Understanding these genetic factors, including inflammation and comorbidities, offers new avenues for personalized frailty interventions.
Area of Science:
- Gerontology and Genetics
- Molecular Biology and Aging
- Immunology and Inflammation
Background:
- Aging involves cumulative damage, impacting physiological reserve and homeostasis.
- Frailty is a dynamic geriatric syndrome linked to inflammation, immunosenescence, and genetic factors.
- Genetic alterations play a role in the development and progression of frailty.
Purpose of the Study:
- To review recent findings on the genetic basis of frailty.
- To explore the link between frailty, genetic polymorphisms, and inflammation.
- To examine the genetic relationship between frailty and chronic comorbidities.
Main Methods:
- Narrative review of current scientific literature.
- Analysis of genome-wide association studies (GWAS) related to frailty.
- Examination of specific genetic polymorphisms impacting inflammatory pathways.
Main Results:
- Genetic factors are significantly associated with frailty.
- Specific polymorphisms influence inflammatory responses contributing to frailty.
- A genetic link exists between frailty and various chronic diseases.
Conclusions:
- Genetics provides a crucial framework for understanding frailty's etiopathogenesis.
- Genetic insights open doors for developing individualized frailty interventions.
- Further research into genetic determinants can enhance frailty management strategies.
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