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Updated: Apr 14, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
Published on: July 14, 2016
Frailty and genetics: linking molecular aging to clinical vulnerability
Jhuliana Castillo1, Natalia García2, Fernando Gómez1
1Research Group on Geriatrics and Gerontology, Faculty of Health Sciences, Universidad de Caldas, Manizales, Colombia.
None:
Aging is a multifactorial process involving cumulative cellular and molecular damage, directly affecting physiological reserve and homeostasis. In this context, frailty emerges as a complex, dynamic, and potentially reversible geriatric syndrome, associated with inflammatory dysregulation, immunosenescence, and genetic alterations. This narrative review presents the most recent findings linking frailty to genetic factors, including genome-wide association studies and specific polymorphisms related to inflammation. The genetic relationship between frailty and various chronic comorbidities is also explored. This genetic perspective provides a promising framework for a better understanding of the etiopathogenesis of frailty and highlights new opportunities for individualized interventions.
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