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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

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Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
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Genetic Variation01:25

Genetic Variation

1.6K
Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles,...
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Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
20.1K
Histone Variants at the Centromere02:30

Histone Variants at the Centromere

5.3K
Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
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Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

14.1K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Related Experiment Video

Updated: Apr 14, 2026

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
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Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

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EBV Genome Variations and Association With Diseases.

Xueer Lin1, Jingtong Liang1, Qiuting Zhang1

  • 1State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China.

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|April 13, 2026
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Epstein-Barr virus (EBV) genomic variations are linked to diseases like cancer and MS. Understanding EBV genomics aids in developing targeted diagnostics and therapies for EBV-related conditions.

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Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
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Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA

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Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
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Last Updated: Apr 14, 2026

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Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
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Area of Science:

  • Virology
  • Genomics
  • Immunology

Background:

  • Epstein-Barr virus (EBV) is linked to various diseases, including cancers and autoimmune disorders.
  • Advances in deep sequencing have revealed geographic patterns in EBV strain distribution.
  • The precise role of EBV genomic variation in disease pathogenesis requires further elucidation.

Purpose of the Study:

  • To review current knowledge on EBV genomic variation and its role in disease development.
  • To explore the evolutionary origins and mechanisms of EBV genetic diversity.
  • To discuss the clinical implications of EBV genomics for diagnostics and therapeutics.

Main Methods:

  • Literature review consolidating studies on EBV genomic variation.
  • Analysis of factors contributing to EBV genetic diversity (replication errors, recombination, immune selection).
  • Summary of associations between EBV subtypes and specific diseases.

Main Results:

  • EBV genetic variations arise from replication errors, recombination, and immune-driven selection.
  • Specific EBV genetic variations are linked to malignancies, infectious mononucleosis, and multiple sclerosis.
  • Mechanisms include altered viral function, host interactions, and molecular mimicry.

Conclusions:

  • EBV genomic variation influences disease pathogenesis through viral and host factors.
  • Genomic insights can drive development of novel diagnostic biomarkers and targeted therapies.
  • Understanding EBV genomics is crucial for addressing the global burden of EBV-related diseases.