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Thiol post-translational modifications modulate allosteric regulation of the OpcA-G6PDH complex through

Hoshin Kim1, Song Feng2, Pavlo Bohutskyi2,3

  • 1Physical Sciences Division, Physical and Computational Sciences Directorate, Pacific Northwest National Laboratory, Richland, Washington, USA.

Protein Science : a Publication of the Protein Society
|April 13, 2026
PubMed
Summary

Redox post-translational modifications (PTMs) on the OpcA protein in cyanobacteria fine-tune glucose-6-phosphate dehydrogenase (G6PDH) activity. These thiol modifications on OpcA regulate G6PDH structure and function, enabling rapid metabolic adaptation to environmental changes.

Keywords:
PTM‐psiallosteric regulationoxidative pentose phosphate pathwayredox post‐translational modificationredox proteomicsregulatory protein–protein interactions

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