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Interleukin-11: A pivotal player and potential therapeutic target in prostate cancer
Jinghua Zhong1,2,3,4, Xiaolu Duan1,2,3,4, Ziyi Wei5
1Department of Urology, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Abstract:
Interleukin-11 (IL-11), a pleiotropic cytokine belonging to the interleukin-6 (IL-6) family, is implicated in the initiation and progression of various malignancies. Recent studies revealed that IL-11 plays multifaceted roles in prostate cancer, contributing to tumor cell proliferation, castration resistance, bone metastasis, and chemotherapeutic resistance. Interleukin-11 has emerged as a promising target for both diagnostic and therapeutic strategies. This review outlines the molecular structure and biological functions of IL-11; summarizes its role in early diagnosis, prognostic evaluation, tumor progression, and therapeutic intervention for prostate cancer; and explores its potential as a novel therapeutic target.

