Related Experiment Video
Updated: Apr 14, 2026
Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Age-stratified differences in asymptomatic primary hyperparathyroidism: a single-center cohort study from 2017 to
Zihan Lin1, Fan Yu2, Hangzhou Yang1
1Department of General Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background:
Primary hyperparathyroidism (PHPT) is increasingly diagnosed as asymptomatic due to routine biochemical screening. While parathyroidectomy (PTX) is the definitive treatment, age-specific management strategies for asymptomatic patients remain contentious, particularly in patients >50 years. Current evidence lacks detailed comparisons of disease characteristics and surgical outcomes across age-stratified asymptomatic cohorts. This study aims to bridge this information gap.
Methods:
This retrospective cohort study analyzed 199 asymptomatic PHPT patients who underwent PTX at Shanghai Sixth People's Hospital between 2017 and 2024. Data regarding demographics, biochemical parameters, imaging data, surgical details, complications and outcomes were collected and compared by age at diagnosis (≤50 or >50 years).
Results:
Among 199 patients who underwent PTX, 128 (64.3%) were >50 years old and 71 (35.7%) were ≤50. Patients in the younger cohort (≤50 years) exhibited significantly lower preoperative 25-hydroxyvitamin D levels (P<0.001), larger parathyroid adenomas (P=0.049), stronger correlations between adenoma volume and preoperative serum parathyroid hormone (PTH) and calcium levels (P<0.001), longer operative durations (P=0.01), and higher rates of endoscopic parathyroidectomy (EPTX) (P<0.001). Quadrant-level localization accuracy via ultrasonography was significantly higher in younger patients (85.5% vs. 71.9%; P=0.03; V=0.15). Transient hypocalcemia occurred more frequently in patients ≤50 years (18.3% vs. 13.3%), although this difference was not statistically significant (P=0.34). No significant intergroup differences were observed in other postoperative complications or cure rates.
Conclusions:
Patients ≤50 years demonstrated superior preoperative localization accuracy, which was associated with larger tumor size. Patients >50 years exhibited a non-significantly lower trend in transient hypocalcemia. Both age cohorts achieved comparably high surgical cure rates, supporting the efficacy of PTX across age groups for asymptomatic PHPT.
More Related Videos
07:12Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
Published on: August 17, 2022
07:13Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
Published on: March 14, 2017
Related Concept Videos
00:59The Parathyroid Glands
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
01:17Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...