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Advancing Drug Delivery with Biodegradable Molecularly Imprinted Polymers: From Design to Clinical Prospects
Angela Alysia Elaine1, Rozana Othman2, Soraya Ratnawulan Mita3
1Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, West Java, Indonesia.
Drug Design, Development and Therapy
|April 13, 2026
Summary
Biodegradable molecularly imprinted polymers (MIPs) show promise for drug delivery systems (DDS). Research focuses on design strategies and degradation mechanisms to overcome challenges for clinical translation.
Area of Science:
- Polymer Chemistry
- Materials Science
- Biomedical Engineering
Background:
- Molecularly imprinted polymers (MIPs) offer advantages for drug delivery systems (DDS), including selectivity, stability, and controlled release.
- Clinical translation of MIP-DDS is hindered by safety, biodegradability, and regulatory concerns.
Purpose of the Study:
- To discuss advances in biodegradable MIP-DDS.
- To highlight key design strategies, degradation mechanisms, and translational challenges.
- To explore the development of clinically viable imprinted drug delivery platforms.
Main Methods:
- Incorporation of degradable monomers and crosslinkers into MIP-DDS.
- Tailoring polymerization strategies to influence recognition site efficiency and degradation rates.
- Systemic evaluation of biocompatibility, toxicity, and degradation mechanisms.
Main Results:
- Degradable monomers and crosslinkers, along with specific polymerization strategies, are crucial for controlling drug release and degradation.
- Stimuli-responsive bond cleavage, hydrolysis, and surface erosion are key degradation pathways.
- Careful design and evaluation are essential for successful clinical translation.
Conclusions:
- Biodegradable MIP-DDS represent a promising avenue for advanced drug delivery.
- Addressing safety, biodegradability, and regulatory hurdles is critical for clinical implementation.
- Further research into design, degradation, and systemic evaluation will facilitate the development of viable imprinted drug delivery platforms.
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