Related Experiment Video
Updated: Apr 14, 2026
06:06
Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
Published on: July 22, 2021
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Osteoarthritis: Epidemiology, Pathogenesis, and Treatment
Tianrui Chen1,2, Wenlong Chen1,2, Tianpeng Xu1
1Orthopedics and Sports Medicine Center Suzhou Municipal Hospital The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Jiangsu China.
Medcomm
|April 13, 2026
Summary
Osteoarthritis (OA) is a complex joint disease driven by inflammation and metabolic issues. This review explores OA
Area of Science:
- Orthopedics and Rheumatology
- Molecular Biology
- Genetics
Background:
- Osteoarthritis (OA) is a leading cause of disability, now understood as a whole-joint disease.
- Pathological changes involve cartilage, synovium, and subchondral bone, driven by inflammation, metabolic issues, and oxidative stress.
- Signaling networks and epigenetic mechanisms regulate OA pathogenesis.
Purpose of the Study:
- To provide an integrated overview of osteoarthritis (OA) epidemiology, pathogenesis, and treatment.
- To elucidate the role of histone methylation in OA.
- To summarize current and emerging OA treatment strategies.
Main Methods:
- Comprehensive literature review of osteoarthritis (OA) epidemiology, pathology, and molecular mechanisms.
- Focus on signaling pathways and epigenetic regulation, particularly histone methylation.
- Analysis of current nonpharmacological, pharmacological, injectable, and surgical treatments.
Main Results:
- OA involves complex interactions between inflammation, metabolic dysregulation, and cellular responses.
- Epigenetic mechanisms, especially histone methylation, significantly impact OA gene expression and progression.
- Histone methylation is implicated in OA-related inflammation, metabolic imbalance, and tissue remodeling.
Conclusions:
- Understanding the interplay between signaling networks and epigenetic regulation, particularly histone methylation, is crucial for OA.
- Integrated therapeutic strategies targeting molecular pathways and epigenetic modifications hold promise for OA treatment.
- This review offers a comprehensive resource on OA, from epidemiology to treatment options.
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