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Risk Factors for Venous Thromboembolism in Advanced Non-Small Cell Lung Cancer: A Nationwide Administrative Database
Tetsuya Kimura1,2, Yugo Yamashita3, Yasutaka Ihara1,4,5
1Department of Medical Statistics, Graduate School of Medicine, Osaka Metropolitan University Osaka Japan.
Circulation Reports
|April 13, 2026
Summary
This study identified key risk factors for venous thromboembolism (VTE) in advanced non-small cell lung cancer (NSCLC) patients receiving chemotherapy. Findings highlight the need for targeted VTE prevention strategies in high-risk individuals.
Area of Science:
- Oncology
- Cardiology
- Epidemiology
Background:
- Non-small cell lung cancer (NSCLC) significantly increases the risk of venous thromboembolism (VTE).
- Limited data exists on specific VTE risk factors in advanced NSCLC patients undergoing chemotherapy.
Purpose of the Study:
- To identify and analyze significant risk factors for VTE in patients with advanced NSCLC receiving first-line chemotherapy.
- To inform the development of risk-stratified monitoring and prophylactic strategies.
Main Methods:
- Analysis of a Japanese nationwide administrative database of 20,206 advanced NSCLC patients treated between January 2016 and January 2023.
- VTE event identification using ICD-10 codes and imaging studies.
- Cox proportional hazards models with time-dependent covariates were used to evaluate risk factors.
Main Results:
- The cumulative incidence of VTE was 4.2% at 1 year and 6.1% at 2 years post-chemotherapy.
- Identified risk factors include female sex, higher BMI, prior VTE, platinum-based chemotherapy, anti-VEGF agents, heart failure, and stroke/TIA.
- Hazard ratios (HR) and 95% confidence intervals (CI) were calculated for each risk factor.
Conclusions:
- This large-scale study identified significant VTE risk factors in advanced NSCLC patients.
- Findings underscore the necessity for risk-stratified monitoring and preventative measures to mitigate VTE complications.
- Targeted interventions can improve outcomes for high-risk NSCLC patients prone to VTE.
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