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Parameter-efficient fine-tuning with layer pruning on medical sequence-to-sequence modeling.
Yunqi Zhu1,2,3, Yuanyuan Wu3, Wensheng Zhang1,2,3
1Guangzhou University, Guangzhou, China.
Health Information Science and Systems
|April 13, 2026
Summary
We developed a parameter-efficient fine-tuning (PEFT) framework integrating LoRA and structured layer pruning. This method significantly reduces memory usage and training time for large language models while maintaining high generation quality.
Area of Science:
- Natural Language Processing
- Artificial Intelligence
- Machine Learning
Background:
- Large language models (LLMs) require efficient fine-tuning methods.
- Parameter-efficient fine-tuning (PEFT) techniques like LoRA freeze most parameters and add trainable ones for downstream tasks.
- Further optimization is needed to reduce computational costs.
Purpose of the Study:
- To propose and validate an integrated framework combining LoRA and structured layer pruning for enhanced PEFT.
- To assess the framework's efficiency in terms of memory usage and training speed.
- To evaluate the impact on generation quality across various NLP tasks.
Main Methods:
- Integrated LoRA with structured layer pruning.
- Tuned only 0.6% of model parameters.
- Pruned over 30% of Transformer layers.
- Validated on medical report summarization, medical dialogue, news summarization, and text generation datasets.
Main Results:
- Reduced GPU memory usage by 50%.
- Increased training speed by 100%.
- Preserved over 92% of generation quality based on ROUGE scores for Seq2Seq tasks.
- Demonstrated effectiveness on diverse datasets, including medical and general text generation.
Conclusions:
- The integrated PEFT framework offers significant efficiency gains for LLMs.
- This approach is effective for both specialized (medical) and general NLP tasks.
- The method balances computational efficiency with high performance in text generation.
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