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Parameter-efficient fine-tuning with layer pruning on medical sequence-to-sequence modeling.

Yunqi Zhu1,2,3, Yuanyuan Wu3, Wensheng Zhang1,2,3

  • 1Guangzhou University, Guangzhou, China.

Health Information Science and Systems
|April 13, 2026
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Summary
This summary is machine-generated.

We developed a parameter-efficient fine-tuning (PEFT) framework integrating LoRA and structured layer pruning. This method significantly reduces memory usage and training time for large language models while maintaining high generation quality.

Keywords:
Language modelingLayer pruningParameter-efficient fine-tuningSequence-to-sequence

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Area of Science:

  • Natural Language Processing
  • Artificial Intelligence
  • Machine Learning

Background:

  • Large language models (LLMs) require efficient fine-tuning methods.
  • Parameter-efficient fine-tuning (PEFT) techniques like LoRA freeze most parameters and add trainable ones for downstream tasks.
  • Further optimization is needed to reduce computational costs.

Purpose of the Study:

  • To propose and validate an integrated framework combining LoRA and structured layer pruning for enhanced PEFT.
  • To assess the framework's efficiency in terms of memory usage and training speed.
  • To evaluate the impact on generation quality across various NLP tasks.

Main Methods:

  • Integrated LoRA with structured layer pruning.
  • Tuned only 0.6% of model parameters.
  • Pruned over 30% of Transformer layers.
  • Validated on medical report summarization, medical dialogue, news summarization, and text generation datasets.

Main Results:

  • Reduced GPU memory usage by 50%.
  • Increased training speed by 100%.
  • Preserved over 92% of generation quality based on ROUGE scores for Seq2Seq tasks.
  • Demonstrated effectiveness on diverse datasets, including medical and general text generation.

Conclusions:

  • The integrated PEFT framework offers significant efficiency gains for LLMs.
  • This approach is effective for both specialized (medical) and general NLP tasks.
  • The method balances computational efficiency with high performance in text generation.