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Chitosan-Stabilized Silver-Nimesulide Coordination Complex with Enhanced Anti-Inflammatory and Redox-Modulating
Luis Eduardo M Narvaez1, Kely C N Lima2,3, Roseane G Ferreira2,3
1Health Science Institute, Federal University of Pará, Belém 66075900, Brazil.
ACS Omega
|April 13, 2026
Summary
This study developed a novel chitosan-stabilized silver-nimesulide complex to combat inflammation and oxidative stress. The biocomposite demonstrated significant anti-inflammatory effects and improved drug delivery for potential disease treatment.
Area of Science:
- Biomaterials Science
- Medicinal Chemistry
- Pharmacology
Background:
- Inflammation and oxidative stress are key factors in many acute and chronic diseases.
- Current treatments often have limitations in efficacy and delivery.
- Developing advanced drug delivery systems is crucial for improved therapeutic outcomes.
Purpose of the Study:
- To engineer a chitosan-stabilized silver-nimesulide coordination complex.
- To enhance the anti-inflammatory and redox-modulating properties of nimesulide.
- To achieve controlled drug release for improved therapeutic performance.
Main Methods:
- Formation of a silver-nimesulide coordination complex within a chitosan matrix.
- Characterization using spectroscopic and crystallographic analyses.
- In vivo evaluation of anti-inflammatory activity (carrageenan-induced edema) and oxidative stress markers (MPO activity, lipid peroxidation).
Main Results:
- Confirmed the formation of the Ag-NMS coordination complex embedded in chitosan.
- Demonstrated significant reduction in edema, MPO activity, and lipid peroxidation in vivo.
- Showcased modulation of thiol-dependent redox responses, indicating effective redox modulation.
Conclusions:
- Coordination-driven polymeric stabilization enhances the therapeutic profile of nimesulide.
- The developed biocomposite exhibits potent anti-inflammatory and antioxidant properties.
- This multifunctional biocomposite warrants further preclinical investigation for therapeutic applications.
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