Related Experiment Video
Updated: Apr 14, 2026
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Lipoprotein combined index and prevalent hyperuricemia among normolipidemic oilfield workers: a cross-sectional study
Haobiao Liu1,2, Jing Tang2, Yingjie Cai2
1Xi'an Gem Flower Changqing Hospital, Xi'an, Shaanxi, China.
Objectives:
The lipoprotein combined index (LCI) reflects composite lipid metabolic patterns and may capture subtle metabolic disturbances beyond conventional lipid markers. Evidence regarding its relationship with hyperuricemia among normolipidemic individuals is scarce. This study investigated the association between LCI and hyperuricemia in an occupational population with normal lipid levels.
Methods:
A total of 2,029 normolipidemic oilfield workers were included. Hyperuricemia was primarily defined using sex-specific serum uric acid thresholds. Associations between LCI and hyperuricemia were examined using logistic regression, with dose-response relationships explored by restricted cubic spline (RCS) analysis. Prespecified subgroup and multiple sensitivity analyses were conducted to assess robustness.
Results:
Hyperuricemia prevalence rose from 9.25% in the lowest LCI quartile to 28.99% in the highest. In fully adjusted models, each standard deviation increase in LCI was associated with a 37% higher odds of hyperuricemia (OR = 1.37, 95% CI: 1.20-1.58, P < 0.001). Compared with the lowest quartile, participants in the highest quartile had more than double the odds (OR = 2.18, 95% CI: 1.45-3.30, P < 0.001), with a significant linear trend (P for trend < 0.001). RCS analysis further supported a positive and linear association between LCI and prevalent hyperuricemia (P for nonlinear = 0.427). Subgroup analyses showed consistent positive associations across all strata, with numerically higher ORs observed in older and female individuals, and no statistically significant interactions were detected (all P for interaction > 0.05). All sensitivity analyses yielded similar results.
Conclusions:
Higher LCI levels were associated with increased odds of hyperuricemia among normolipidemic oilfield workers. LCI may serve as an early marker of urate-related metabolic dysregulation, offering additional value beyond traditional lipid indicators. Longitudinal studies are warranted to confirm its predictive potential.
Related Concept Videos
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
01:31Lipid-derived Compounds in the Human Body
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
01:18Lipids: Dietary Sources and Requirements
01:24Lipid Absorption
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...