Correlation of CS and OCTA biomarkers in CSCR

To identify Optical Coherence Tomography Angiography (OCTA) biomarkers in eyes with acute Central Serous Chorioretinopathy (CSCR) and assess their correlation with contrast sensitivity (CS).

In this prospective observational study, 32 eyes of 30 patients with acute CSCR underwent OCTA, spectral-domain OCT, and fluorescein angiography. Contrast sensitivity was measured using the Pelli-Robson chart.

OCTA revealed three types of abnormalities: dark areas in all eyes, dark spots in five eyes (associated with serous retinal detachment and pigment epithelium detachment), and abnormal vessels in twelve eyes. Mean baseline CS was 1.42, which improved to 1.78 at six-month follow-up (p < 0.001).

Although OCTA abnormalities varied, the presence of persistent dark areas correlated with reduced contrast sensitivity, emphasizing that structural recovery does not equate to functional recovery.

Although visual acuity normalized in most cases, persistent OCTA abnormalities and reduced CS highlighted ongoing visual quality impairment, indicating that anatomical recovery does not equate to full functional recovery.