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Updated: Apr 14, 2026

Scalable Isolation and Purification of Extracellular Vesicles from Escherichia coli and Other Bacteria
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Scalable Isolation and Purification of Extracellular Vesicles from Escherichia coli and Other Bacteria

Published on: October 13, 2021

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A One Health perspective on bacterial extracellular vesicles as mediators of antimicrobial resistance spread

Haining Huang1, Debjyoti Ghosh1, Anja Worrich1,2

  • 1Department of Applied Microbial Ecology, UFZ - Helmholtz Centre for Environmental Research, Permoserstraße 15, 04318 Leipzig, Saxony, Germany.

ISME Communications
|April 13, 2026
PubMed

Insights

Bacterial extracellular vesicles (BEVs) are key in spreading antimicrobial resistance (AMR) across human, animal, and environmental sectors. Understanding BEVs is crucial for developing effective AMR surveillance and mitigation strategies.

Area of Science:

  • Microbiology
  • Environmental Science
  • Public Health

Background:

  • Antimicrobial resistance (AMR) poses a significant global health challenge.
  • A One Health approach is necessary to address AMR across human, animal, and environmental domains.
  • Bacterial extracellular vesicles (BEVs) are increasingly recognized for their role in AMR.

Purpose of the Study:

  • To synthesize current knowledge on the role of BEVs in AMR transmission.
  • To highlight the cross-sectoral potential of BEVs in AMR.
  • To identify critical research gaps concerning BEVs and AMR.

Main Methods:

  • Literature review of studies investigating BEVs and AMR.
  • Analysis of BEVs' characteristics and functions related to resistance gene transfer.
  • Synthesis of findings across clinical, agricultural, and environmental contexts.

Main Results:

  • BEVs act as vectors for antibiotic resistance genes and mobile genetic elements.
  • BEVs facilitate horizontal gene transfer and protect genetic cargo.
  • BEVs can traverse ecological boundaries, contributing to AMR spread.

Conclusions:

  • BEVs play a significant role in the transmission of antimicrobial resistance.
  • Recognizing BEVs' function is essential for enhancing AMR surveillance.
  • Further research into BEVs is vital for informing future AMR mitigation strategies.
Keywords:
One Healthantimicrobial resistancebacterial extracellular vesicleshorizontal gene transfer

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