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Status quo, challenges and future directions of hydrogen medicine
Shengqiang Chen1, Lingting Zeng1, Qianjun He1
1Shanghai Key Laboratory of Hydrogen Science & Center of Hydrogen Science, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Abstract:
The hydrogen molecule (H2) has distinctive characteristics and advantages in broad-spectrum anti-inflammation, high biosafety and strong tissue permeability, exhibiting a therapeutic potential in numerous diseases associated with inflammation and oxidative stress. In this perspective, we attempt to show a clear picture of the status quo, challenges and future directions of hydrogen medicine in terms of biological mechanisms, metabolic behaviors, and delivery materials and techniques of H2. Firstly, we present the current understanding of biological effects and corresponding mechanisms of H2 involving the recognition of H2 molecular target, and point out the challenge of explaining the multifaceted biological behaviors of H2. Then, to explore and understand the metabolic behaviors of H2, we summarize current H2 detection techniques and identify the experimental validation of high biocarriers-crossing ability of H2 by virtue of a freshly developed H2 molecular bioprobe. Next, to develop the strategies for enhancing the efficacy of hydrogen therapy, we demonstrate the evolution of H2-delivery materials from H2 carriers to hydrolytic and catalytic H2-generating materials. Finally, we outline the future development directions of hydrogen medicine.
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