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Related Experiment Video

Updated: Apr 14, 2026

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Published on: March 29, 2019

RBM11 drives malignant progression of bladder cancer by regulating GNPDA1-PKM2 axis.

Hang Tong¹, Tinghao Li¹, Junlong Zhu¹

¹Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

|April 13, 2026

Summary

This summary is machine-generated.

RNA-binding motif protein 11 (RBM11) drives bladder cancer progression by promoting the GNPDA1-PKM2 axis, which enhances glycolysis and epithelial-mesenchymal transition (EMT). Targeting RBM11 may offer a new therapeutic strategy for bladder cancer.

Keywords:

cancer cell biology molecular physiology

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Area of Science:

Oncology
Molecular Biology
Biochemistry

Background:

Bladder cancer (BCa) remains a significant health concern with complex progression mechanisms.
Understanding the molecular drivers of BCa is crucial for developing effective therapies.

Purpose of the Study:

To investigate the role of RNA-binding motif protein 11 (RBM11) in bladder cancer progression.
To elucidate the molecular mechanisms underlying RBM11's function in BCa.

Main Methods:

Integrated bioinformatics analysis using TCGA database.
Validation in clinical bladder cancer tissues.
In vitro experiments involving RBM11 knockdown and overexpression in BCa cells.
Investigation of RBM11's interaction with GNPDA1 and PKM2.

Main Results:

RBM11 is significantly upregulated in BCa and correlates with advanced stage, poor prognosis, and epithelial-mesenchymal transition (EMT).
RBM11 knockdown suppressed BCa cell migration, invasion, proliferation, and chemoresistance.
RBM11 promotes GNPDA1 expression via alternative splicing and stabilizes PKM2 protein levels, enhancing glycolysis and malignant progression.

Conclusions:

RBM11 drives BCa progression through the GNPDA1-PKM2 axis, impacting glucose metabolism and EMT.
RBM11 represents a potential therapeutic target for bladder cancer treatment.