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Updated: Apr 14, 2026

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

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Phenotyping preserved ratio impaired spirometry (PRISm) using quantitative high-resolution computed tomography

Jun Hu¹, Zhujin Shen², Tong Su³

¹Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Quantitative Imaging in Medicine and Surgery

|April 13, 2026

Summary

This summary is machine-generated.

Preserved ratio impaired spirometry (PRISm) shows distinct radiological phenotypes. Quantitative HRCT parameters correlate with lung function, aiding PRISm patient stratification.

Keywords:

Preserved ratio impaired spirometry (PRISm)high-resolution computed tomography (HRCT)quantitative analysis radiological phenotypes

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Area of Science:

Pulmonary Medicine
Radiology
Medical Imaging

Background:

Preserved ratio impaired spirometry (PRISm) is a common condition linked to increased respiratory risks.
Limited radiological studies exist for PRISm phenotyping.
PRISm is characterized by reduced FEV1 and a normal FEV1/FVC ratio.

Purpose of the Study:

To investigate airway changes in PRISm related to emphysema.
To correlate quantitative high-resolution computed tomography (HRCT) parameters with pulmonary function.
To explore potential PRISm phenotypes using quantitative HRCT.

Main Methods:

Retrospective study of 102 PRISm patients.
Analysis of CT scans and pulmonary function tests (PFTs) within 3 months.
Quantitative and semi-quantitative analysis of parenchyma and airway parameters using specialized software.

Main Results:

Significant differences in total lung capacity (TLC_CT) and wall area percentage (WA%) were observed with emphysema severity.
Mild to moderate correlations found between parenchyma and airway parameters, notably TLC_CT and WA% (r=-0.64).
Four radiological phenotypes of PRISm were identified with significant differences in CT and PFT parameters.

Conclusions:

Quantitative HRCT reveals differences in parenchyma and airway parameters across PRISm phenotypes.
These findings suggest HRCT can aid in stratifying PRISm patients.
A novel radiological approach may improve PRISm patient management.